FOR U.S. AUDIENCES ONLY

ABOUT PSORIASIS
(PsO)

An estimated 7.5 million Americans live with psoriasis. Psoriasis, also known as PsO, is a common autoimmune disease in the U.S. It is a chronic, systemic skin condition related to a problem with the immune system. Psoriasis is not contagious.

PsO SYMPTOMS SPOTLIGHT

Symptoms of Psoriasis Small spots
of scaling
Symptoms of Psoriasis Dry,
cracked skin
Symptoms of Psoriasis Raised, sometimes
red, patches of skin
covered with
silvery scales
Symptoms of Psoriasis Painful patches,
itchy skin
Psoriasis Diagnosis

A FOCUS ON DIAGNOSIS

Psoriasis Diagnosis

There are no special blood tests or tools to diagnose psoriasis. A dermatologist or other doctor usually examines the affected skin and determines if it is psoriasis.

You doctor may take a piece of the affected skin (called a biopsy) and examine it under the microscope.

Your doctor also will want to learn about your family history. About one-third of people with psoriasis have a family member with the disease.

HOW TO MANAGE PsO

Have open
conversations
with your doctor
about your condition
and treatment
Maintain a healthy
weight and diet
Find ways to
minimize stress

PATIENT RESOURCES

A PILL THAT TREATS PLAQUE PSORIASIS OR PSORIATIC ARTHRITIS DIFFERENTLY.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

You must not take Otezla® if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant, or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information.

Otezla® is a registered trademark of Celgene Corporation.

© 2017 Celgene Corporation 08/17
USII-APR170021(1)

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